The purpose of this study was to test the stability of TPN basic solutions containing amino acids and dextrose.
Test solutions containing 4.25% amino acids in 25% dextrose (central TPN basic solution) or 4.25% amino acids in 10% dextrose (peripheral TPN basic solution) were prepared. Two different amino acids solutions (Fravasol^(®) vs Freamine^(®)) were tasted. The samples were taken from each admixture and stored in the evacuated, sterile containers at 2∼8℃ and ambient room temperature. Each sample was analyzed at 0, 3, 7, 14, 30 days of storage. Each amino acid was analyzed by amino acid analyzer. Dextrose content was measured by polarimeter. The pH and chromagen formation were also monitored. The decomposition was measured by the changes in concentration of amino acids and dextrose.
TPN basic solutions admixed with Fravasol^(®) and stored at 2∼8℃ were stable 30 days. Central and peripheral TPN basic solutions stored at room temperature were stable for 7 days and 14 days, respectively. There were no change in color for 30 days by naked eye. Amino acid concentrations in TPN basic solutions admixed with Fravasol^(®) and stored at 2∼8℃ or room temperature were stable for 30 days. But, significant change in color was observed with time.
In conclusion, Peripheral TPN basic solutions admixed with Fravasol^(®) and store at room temperature and in refrigerator were stable for 3 days and 7 days, respectively.
However, central TPN basic solutions admixed with Fravasol^(®) were unstable. Therefore, it is recommended that it should be admixed right before injection.
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